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EEA Grants (2014-2021)

Next Generation Viral Hepatitis B and C vaccine development in plants and algae using advanced biotechnological tools


Project Acronym: SmartVac

Duration: 48 months


Funding: 1.500.000,00 euro


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  2. ro



1) Dobrica MO, Lazar C, Branza-Nichita N.(2020) N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis. Cells. 9(6):E1404. Published 2020 Jun 4. doi:10.3390/cells9061404, IF 5,6


2) A polycarboxylic chelating ligand for efficient resin purification of His-tagged proteins expressed in mammalian systems. (2020) Codruta C. Popescu, Marius C. Stoian, Lia-Maria Cucos, Anca G. Coman, Antonio Radoi, Anca Paun, Niculina D. Hadade, Arnaud Gautier, Costin-Ioan Popescu and Mihaela Matache. RSC Adv., 10, 23931, IF 3, 09


3) Production of Chimeric Hepatitis B Virus Surface Antigens in Mammalian Cells. (2020) Mihaela-Olivia Dobrica, Catalin Lazar and Norica Branza-Nichita. Vaccine Delivery Technology: Methods and Protocols, Methods in Molecular Biology, Blaine Pfeifer and Andrew Hill (eds.), vol. 2183,, © Springer Science+Business Media, LLC, part of Springer Nature. Book chapter.





1) The 49th Conference of the Romanian Society for Immunology &The 4th Conference of the Romanian Association for Immuno-Dermatology. 30.09-3.10.2020 Videoconference:


AM Pantazică*, OM Dobrică*, C Scurtu, N Nichita. "Production and characterization of novel HBV chimeric antigens". *Authors with equal contribution to this work.


LM Cucoș, TA Șulea, L.Spiridon, N Nichita, CI Popescu. “HCV Envelope Protein E2 Antigen Design and Characterization for Vaccine Development”