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Institutul de Biochimie

Departamentul de Glicoproteine Virale

  1. en
  2. ro

 

EEA Grants (2014-2021)

Dezvoltare de vaccinuri de ultima generație împotriva Virusurilor Hepatice B și C în plante și alge, utilizând metode biotehnologice avansate

 

Acronimul proiectului: SmartVac

Durata: 48 de luni

(03/06/2019-02/06/2023)

Finanțare: 7.127.550,00 lei

UEFISCDI

Publicatii:

 

1) N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis. (2020) Dobrica MO, Lazar C, Branza-Nichita N. Cells. 9(6):E1404. Published 2020 Jun 4. doi:10.3390/cells9061404, IF 5,6

 

2) A polycarboxylic chelating ligand for efficient resin purification of His-tagged proteins expressed in mammalian systems. (2020) Codruta C. Popescu, Marius C. Stoian, Lia-Maria Cucos, Anca G. Coman, Antonio Radoi, Anca Paun, Niculina D. Hadade, Arnaud Gautier, Costin-Ioan Popescu and Mihaela Matache. RSC Adv., 10, 23931, IF 4,03

 

3) Production of Chimeric Hepatitis B Virus Surface Antigens in Mammalian Cells. (2020) Mihaela-Olivia Dobrica, Catalin Lazar and Norica Branza-Nichita. Vaccine Delivery Technology: Methods and Protocols, Methods in Molecular Biology, Blaine Pfeifer and Andrew Hill (eds.), vol. 2183, https://doi.org/10.1007/978-1-0716-0795-4_7, © Springer Science+Business Media, LLC, part of Springer Nature. Book chapter.

 

4) Challenges and Prospects of Plant-Derived Oral Vaccines against Hepatitis B and C Viruses. (2021) Pantazica AM, Cucos LM, Stavaru C, Clarke JL, Branza-Nichita N. Plants (Basel), 10, 2037.https://doi.org/10.3390/plants10102037, IF 4,6

 

5) Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus-neutralizing activity in vaccinated mice. (2021) Dobrica MO, van Eerde A, Tucureanu C, Onu A, Paruch L, Caras I, Vlase E, Steen H, Haugslien S, Alonzi D, Zitzmann N, Bock R, Dubuisson J, Popescu CI, Stavaru C, Liu-Clarke J, Branza-Nichita N.  Plant Biotechnology Journal, Oct;19(10):2027-2039, IF 9,8

 

6) Efficient cellular and humoral immune response and production of virus-neutralizing antibodies by the Hepatitis B Virus S/preS116-42 antigen (2022) Pantazica A-M, Dobrica MO, Lazar C, Scurtu C, Tucureanu C, Caras I, Ionescu I, Costcahe A, Onu A, Liu Clarke J, Stavaru C, Nichita N. Frontiers in Immunology, Jul 22;13:941243,  IF 8.78

 

 

 

Conferinte:

 

1) A 49a Conferinta a Societatii Romane de Imunologie si a 4a Conferinta a Asociatiei Romane de Immuno-Dermatologie, 30.09-3.10.2020, Videoconferinta:

 

AM Pantazică*, OM Dobrică*, C Scurtu, N Nichita. "Production and characterization of novel HBV chimeric antigens". *Authors with equal contribution to this work.

 

LM Cucoș, TA Șulea, L.Spiridon, N Nichita, CI Popescu. “HCV Envelope Protein E2 Antigen Design and Characterization for Vaccine Development”

 

3) Simpozionul Anual al INCDMM “Cantacuzino”. 25.11.2021

 

Nichita N, “Production of novel vaccine antigens derived from the Human Hepatitis B Virus” (Key lecture)

 

4) Simpozionul Anual al "Protein Society" (USA), July 7-14, 2021

 

Pantazică A-M, Dobrică MO, Scurtu C, Nichita N, “Production and Characterization of Novel HBV Chimeric Antigens”, (poster presentation)

 

Cucos L-M, Sulea T, Caras I, Spiridon L, Stavaru C, Nichita N, Popescu CI, “Hepatitis C Virus envelope protein E2 based antigen design and characterization for vaccine development”, (poster presentation)

 

5) Conferinta Internationala Anuala a Societatii Romane de Biochimie si Biologie Moleculara, Iași, 26-27 Septembrie, 2019

 

MO Dobrica, L. Paruch, D. Alonzi, N. Zitzmann, CI Popescu, J. Dubuison, J. Liu-Clarke, N. Nichita, “Generation and characterization of HCV-E2 antigen in Nicotiana Benthamiana leaves for vaccine development”, (poster presentation)